thesis
Eicosanoids, endotoxins and liver disease
- Publication date
- 13 December 1985
- Publisher
- Endotoxins are cell wall lipopolysacharides of gram negative
bacteria. The gut contains large numbers of bacteria and is
generally accepted to be a large reservoir of endotoxins. In the
normal state absorbed endotoxins are rapidly removed from the portal
blood by especially the reticulo-endothelial cells of the liver. In
patients with liver disease there is a diminished function of the
reticulo-endothelial system, resulting in a raised frequency of
systemic endotoxemia. Systemic endotoxemia in liver disease, as
measured by the Limulus lysate test, correlates with a higher
frequency of clotting disorders, renal failure and a high mortality
rate