Subcutaneous pancreas transplantation : an experimental study in rats and dogs

Abstract

The aim of this study was to investigate whether subcutaneous pancreas transplantation is a feasible technique which results in long-term insulin-independence, which can be used in early pancreas transplantation, before late diabetic complications will develop. In this surgical model also the third condition for early pancreas transplantation was tested: immunosuppressive protocols with non- or low-toxicity. Especially biological procedures (blood transfusions and anti-class-U donor pretreatment) were used in combination with low-dose immunosuppressive drugs. The studies were performed in an experimental rat model and a preclinical dog model The next specific questions were studied: can long-term pancreas-graft function be achieved if placed in a subcutaneous position? has this position immunological consequences? can effective immunosuppressive protocols be developed with no or minimal sideeffects, resulting in long-term graft function