research
Intravascular ultrasound: validation and clinical application
- Publication date
- 18 December 1996
- Publisher
- Atherogenesis is a process with an insidious onset and course. Once clinical signs and
symptoms have become manifest, the obstructive lesion is usually at an advanced stage.
Arteriography is the standard method for evaluation of atherosclerotic disease and has
been useful in identifying the location and approximate severity of the stenotic lesion.
Although arteriography provides a silhouette of the vessel lumen, it does not provide
accurate knowledge on cross-sectional lumen area, vessel area, shape and morphology of
the stenotic lesion. Intravascular ultrasound (lVUS) may overcome these limitations by
providing a tomographic image of the vessel.
The aim of this work is to validate IVUS and to evaluate subsequent clinical
application of this imaging technique. The subjects dealt with in this dissertation are
categorised into 5 main topics.
I) displacement sensing device;
2) validation of IVUS-derived parameters;
3) the spectrum of vascular morphology before and after intervention determined by
IVUS;
4) IVUS as a research tool;
5) IVUS as a clinical tool