thesis
The ERCC1-xeroderma pigmentosum group F DNA repair complex
- Publication date
- 31 March 1999
- Publisher
- In its long nucleotide-chains, the DNA double helix contains the genetic information
for ten thousands of proteins. The DNA molecule, however, is subject to
constant change. In order to l11ailltaill its integrity, several luechallisms that
cope with DNA damage, inflicted byvarious naturally occurring and man-made
agents, have evolved. Individuals with the rare genetic disease xeroderma
pigmentosum demonstrate the importance of DNA repair systems. These patients
carry a defect in proteins that are involved in the removal ofUV-induced
damage from the DNA, which results in sun-sensitivity and the frequent occurrence
of skin cancers, Hence, studies on DNA repair and human repah' disorders
such as xeroderma pigmentosum