A plastic compound used in some dermal fillers for the correction of wrinkles that are filled with a substance and released as the shell disintegrates Controlled release delivery Biodegradable microspheres are used to control drug release rates thereby decreasing toxic side effects, and eliminating the inconvenience of repeated injections. Microparticulate carrier system can be administered through different routes such as i.v,ocular,i.m,oral,intra arterial.etc.Each routes has it's own biological significance, limitation & pharmaceutical feasibility. Keywords: wrinkles, Biodegradable microspheres, Microparticulate, injections, control drug release.Â