This review by the International Center for Research on Women explores the specific issues that cluster around the provision of care in the context of the global HIV/AIDS pandemic. With the support of the Population Council’s Horizons program, this review applies the care economy lens to two key sectors, health and social protection, and finds that while important strides are being made, much more needs to be known and done to enable individuals, families, and households to survive in a world shaken by AIDS. The report documents the challenges faced by family care providers, who are primarily women and unlinked to existing services; responses by the health sector and the community to support caregivers, including the involvement of youth and men in caregiving; and government- and private-sector–sponsored social protection programs to help sustain the safety nets of households affected by HIV/AIDS