Sitkowska, Kaja Dorota

University of Groningen

   University of GroningenPhotoresponsive antibiotics and cytotoxic agentsSitkowska, Kaja DorotaIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2019Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Sitkowska, K. D. (2019). Photoresponsive antibiotics and cytotoxic agents: On the use of light for theadvancement of medicine and the knowledge of living organisms. [Groningen]: University of Groningen.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 13-11-2019Photoresponsive antibiotics and cytotoxic agents  On the use of light for the advancement of medicine and the knowledge of living organisms             Kaja Dorota Sitkowska   On the cover: The reader will discover a dragon sleeping on treasure who symbolizes the photoprotecting groups greedily blocking the activity of drugs. The brave little hamster, incoming from the back cover with his flashlight to challenge the dragon, represents us in our attempts at the light-driven deprotection of these compounds. The story continues after the acknowledgements. Praise the sun.          © K. D. Sitkowska, 2019 No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form by any means, without permission of the author, or, when appropriate, of the Publisher of the publication or illustration material.  We gratefully acknowledge the generous support from NanoNed, The Netherlands Organization for Scientific Research (NWO−CW, Top grant to B.L.F. and VIDI grant no. 723.014.001 for W.S.), the Royal Netherlands Academy of Arts and Sciences Science (KNAW), the Ministry of Education, Culture and Science (Gravitation program 024.001.035), the European Research Council (Advanced Investigator Grant, no. 694435 to B.L.F) and the UBBO EMMIUS program.   ISBN  Electronic version: 978-94-034-1612-0 Printed version: 978-94-034-1613-7  Cover design: Kaja Sitkowska Design and lay-out: Kaja Sitkowska, Dr. Jean-Baptiste Gualtierotti Printed by: Ipskamp Printing B. V., Enschede, The Netherlands    Photoresponsive antibiotics and  cytotoxic agents  On the use of light for the advancement of medicine and the knowledge of living organisms   PhD Thesis  to obtain the degree of PhD at the  University of Groningen on the authority of the Rector Magnificus prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on   Friday 26 April 2019 at 16.15 hours   by   Kaja Dorota Sitkowska  born on 15 June 1988 in Nowy Dwór Mazowiecki, Poland   Supervisors Prof. B. L. Feringa  Prof. G. Litwinienko   Co-supervisor Prof. W. C. Szymański   Assessment Committee Prof. P. H. Elsinga Prof. M. D. Witte  Prof. A. J. Minnaard Prof. M. K. Cyrański       In collaboration with        University of Warsaw Faculty of Chemistry     Table of Contents Chapter 1 On the use of light to study biological processes Introduction 2 Visualization of diseases – fluorescent probes 9 Controlling the activity of drugs – molecular switches and photoprotecting groups 13 Molecular switches 19 Photoprotecting groups 22 Outline of the thesis 28 References 30 Chapter 2 Green-light-sensitive BODIPY photoprotecting groups for amines Introduction 36 Results and discussion 40 Conclusion 49 Experimental Procedures 50 References 63 Chapter 3 Red – light – sensitive BODIPY photoprotecting groups for biological applications Introduction 68 Results and discussion 71 Conclusion 77 Experimental procedures 78 References 86 Chapter 4 Meso formyl BODIPY dyes as building blocks for multicomponent Passerini reactions Introduction 90 Results and discussion 95 Conclusions 108 Experimental procedures 109 References 118 Chapter 5 Photoprotection of a model antibiotic and anticancer agent General Overview of the Two Sections 122 Photocleavable Mitomycin C: towards limiting the side effects of HIPEC therapy Introduction 123 Results and discussion 131 Conclusions 139 Experimental procedures 140 Photocleavable Neomycin: preventing the buildup of bacterial resistance against aminoglycoside antibiotics Introduction 145 Results and discussion 151 Conclusions 157 Experimental procedures 158 References 161 Chapter 6. Gold nanoparticle-BODIPY fluorescence probes as indicators of oxidative stress Introduction 166 Results and discussion 178 Conclusions 189 Experimental procedures 190 References 201 Conclusions and Future Prospects Conclusion 205 Future prospects 206 Summaries, table of abbreviations, author contributions and acknowledgements. English Summary 210 Dutch Summary 212 Polish Summary 215 Table of Abbreviations 219 Author Contributions 222 Acknowledgments 224    

Photoresponsive antibiotics and cytotoxic agents:On the use of light for the advancement of medicine and the knowledge of living organisms

https://pure.rug.nl/ws/files/79897794/Title_and_contents.pdf

Photoresponsive antibiotics and cytotoxic agents:On the use of light for the advancement of medicine and the knowledge of living organisms

Abstract

Similar works

Full text

Available Versions

University of Groningen