The compatibility of a low concentration of hydrocortisone sodium succinate with selected drugs during a simulated Y-site administration

Abstract

Objectives: Bolus dose concentrations of hydrocortisone (50 mg/mL) are reported to be incompatible with midazolam and ciprofloxacin in Y-site mixing studies. We evaluated the physical and chemical compatibility of low concentrations of hydrocortisone sodium succinate (1 mg/mL) with midazolam (1 mg/mL and 2mg/mL) and ciprofloxacin (2 mg/mL) solutions during a simulated Y-site administration study