Human papillomavirus (HPV) is the most common sexually transmitted disease (STD) in the United States (Seto, Marra, Raymakers, & Marra, 2012). A literature review was conducted to investigate the barriers to vaccine uptake in the male population. Barriers were categorized into three main categories including lack of education, perceived fears, and inaccessibility. The review of literature revealed that education is critical in breaking through the barriers inhibiting the uptake of the HPV vaccine. Following the literature review a clinical article was submitted to the Journal of Pediatric Nursing for consideration for publication