Objective: Our objective was to use RBC cholinesterase and POP scale at admission for
prognosis. We also looked at atropine toxicity, rates of complications, and outcomes in
organophosphorus and carbamate poisoning.
Methods:
It was prospective cohort study of 1 year duration including patients with
organophosphorus and carbamate poisoning.
The data was collected by the principal investigator and followed up the patients daily till
discharge. The baseline BChE and RBC AChE were collected at admission.
Data entry using epidata software and was analyzed by SPSS software.
Statistical method:
t-test was used for analysis of continuous data with Normal distribution and Mann-
Whitney U test for data with non- Normal distribution. Chi-square test was performed for
categorical variables. Differences were considered significant at p value of <0.05.
Results: Out of 60 patients in the study, 18(30%) patients developed intermediate
syndrome.33 required ICU admission and mechanical ventilation of which14 required
tracheostomy for prolonged ventilation. 3 patients died.
RBC cholinesterase levels and POP scale at admission had statistical significant relation
with the initial and total atropine requirements. POP scale also predicted the need for
intubation and ICU stay. Atropine toxicity was common 60% but mild.
We conclude that RBC cholinesterase and POP scale be used as new standards for
assessment and guiding management of patients with organophosphorus and carbamate
poisoning
