The present investigation concerns the seasonal change of angiosperm diversity and physico-chemical characteristic of water and soil in Ramgarh wetland, Gorakhpur, Uttar Pradesh, India. In this region, the wetlands are commonly called as ‘Tals’ or ‘Pokharas’ i.e. a true natural wetlands. The prominent wetlands of the district include Ramgarh Tal, Chilua Tal, Mahesra Tal etc. This investigation also encompass with the economic prospect of wetland associated angiosperm. Diversity indices of 48 plant species and the regulatory effects of the 10 physico-chemical parameters of water and soil on the plant diversity were assessed. The angiosperm diversity, richness and evenness were high in monsoon but the dominancy was high in the months of mid summer and mid winter because very few species tolerate that adverse condition i.e., high cold and high hot condition. Due to seasonal variation of angiosperm diversity and physico-chemical parameters of soil and water it was revealed that the wetland plants diversity were changed with the seasonal i.e. premonsoon, monsoon and postmonsoon changes of physico-chemical parameters