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Changing world of neutrophils
Authors
A Hakkim
A Mantovani
+124 more
A Porcherie
AM Houghton
AR Martineau
B Gyorgy
B Gyorgy
B McDonald
BG Yipp
BK Rada
C Andrei
C Beauvillain
C Beauvillain
C Costantini
C Eken
C Eken
C Eken
C Hess
C Kantari
C Kudo
C Kudo
C Nathan
C Porro
C Summers
C Thery
CF Urban
CI Timar
CN Jenne
Csaba I. Timár
CY Lee
D Yang
D Yang
DL Bratton
DS Abi Abdallah
E Cocucci
E Kolaczkowska
E Pluskota
E Vijver van de
EM Kang
EP Reeves
Erzsébet Ligeti
F Colotta
F Jonsson
F Semeraro
G Camussi
G Raposo
GS Garcia-Romo
H Valadi
I Bournazou
I Bournazou
I Nagaoka
J Dalli
J Pillay
J Watanabe
JT Buchanan
JW Kim
K Al-Nedawi
K Kambas
K Kessenbrock
K Theilgaard-Monch
K Theilgaard-Monch
KC Vickers
KP Gisbergen van
KW Li
L Daniel
L Deban
LA Pekarek
M Bianchi
M Drechsler
M Mack
M Mesri
M Mesri
M Thewissen
MA Cassatella
MA Cassatella
MC Dinauer
MJ Walker
ML Bruhl von
N Borregaard
N Maugeri
NC Peters
O Gasser
O Gasser
O Soehnlein
P Gonzalez-Cano
P Scapini
P Scapini
P Wolf
PG Barlow
PS Prakash
PV Vignais
R Darbousset
R Lande
R Manzenreiter
R Nieuwland
R Rotondo
RI Dewalt
RJ Berckmans
RT Megens
S Bhatnagar
S Massberg
S Nourshargh
S Sadallah
S Sadallah
S Sadallah
S Sadallah
S Schmidt
S Talukdar
SD Kobayashi
SD Kobayashi
SM Holland
T Chtanova
T Saitoh
TA Duarte
TA Fuchs
TD Lee
V Abadie
V Brinkmann
V Brinkmann
V Witko-Sarsat
V Witko-Sarsat
WM Nauseef
Y Doring
Y Hong
Y Qu
Ákos M. Lőrincz
Publication date
1 January 2013
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
Neutrophilic granulocytes are no longer regarded as cells involved only in the last phase of the immune response with one single-although vitally important-task: engulfing and killing of microorganisms marked by immunoglobulin or complement fragments. In recent years, it was shown that neutrophils are actively involved in initiation and organization of the adaptive immune response by releasing various cytokines, interacting with all major types of immune cells, regulating their own lifespan, and participating in the anaphylactic reaction and in several classically nonimmune functions such as hemostasis, atherogenesis, and even insulin resistance. The antibacterial effect is no longer restricted to killing and destruction of microorganisms sequestered in the phagosomal space. Bacteriostasis also occurs at certain locations of the extracellular space, by formation of neutrophil extracellular traps (NETs) that were shown in the last 2 years to have a significant role in the prevention of dissemination of microorganisms. Extracellular vesicles represent a recently discovered form of intercellular communication carried out both by lipids, proteins, and nucleic acids. In this review, we also summarize the role of neutrophil-derived extracellular vesicles in modifying the function of other cell types as well as their direct antibacterial effect that differs significantly from mechanisms applied either by neutrophils or by the NETs. © 2013 Springer-Verlag Berlin Heidelberg
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oai:repo.lib.semmelweis.hu:123...
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oai:real.mtak.hu:7439
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Crossref
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info:doi/10.1007%2Fs00424-013-...
Last time updated on 28/03/2019