Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR signal: a Study using Expression-controlled Aquaporin4 Cells

Abstract

We performed multi-b-value and multi-diffusion-time DWI on AQP4-nonexpressed (noAQ) and AQP4-expressed (AQ) cells to investigate the effect that CMP has on diffusion-weighted magnetic resonance signal. Significant signal differences between the noAQ and AQ cells were observed only at high b-values. Diffusion-time dependent ADC changes were also observed, but there were no significant differences between the noAQ and AQ cell samples.ISMRM 20th Annual Meeting & Exhibitio

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