This study was conducted to detect the present of Oxacillin resistant Staphylococcus aureus (ORSA) and its antibiotic susceptibility pattern among service workers attending Al-Nu'man Hospital, Baghdad from January to December, 2015. Oxacillin resistant Staphylococcus aureus (ORSA) is known to be multidrug resistant and thus difficult to treat, its causes severe morbidity and mortality worldwide. The results of the current study shows a total of 600 Staphylococcal isolates were isolated from service workers. Out of them, 165 (27.5%) isolates were coagulase positive staphylococci (CPS) and 435 (72.5%) isolates were coagulase negative staphylococci (CNS), 78 (21%) of S. aureus exhibited oxacillin resistance. The present study shows increase the resistant of ORSA to commonly use antimicrobials. The results highlight the need for effective implementation of community infection control measures among service workers. There is a need for the judicious use of antimicrobial agents among service workers. As their indiscriminate use can exert pressure in selecting out Oxacillin resistant Staphylococcus aureus (ORSA) and other multidrug Bacteria
