AbstractBackground.Resistance to antibiotics arising in Escherichia coli and Klebseilla species isolates may complicate therapeutic management of urinary tract infection(UTI) by this organism.Aim. The aim of this study was to assess antibiotic activity against UTI isolates of E.coli in Al- Najaf governorate.Methodology. Atotal of 81 mid –stream urine samples were collected from patient suspected of UTI and screened for the occurrence of E.coli.Result. Susceptibility of the isolates to antibiotics was test by standard methods. Highest rate of resistance (100%) was found toampicillin and amoxicillin, while moderately resistant to cephalothin .Conclusion.The present study concluded that E.coli resistance to multiple antibiotic were recognized.Keywords: Urinary tract infection, Escherichia coli , Klebseilla, Resistant to antibiotic
