Ixora is a large genus of about 400 species of popular evergreen shrubs and small trees, many of which are native to southern china, India and Srilanka and belong to the taxonomic family rubiaceae. A few of these species are grown in gardens for their vibrantly coloured flowers produced in large clusters at the tips of branches. Various species of Ixora are otherwise called as West Indian Jasmine, Jungle Flame, Flame of the World, Jungle Geranium etc., but are very popular by the genus name, Ixora.
Ixora is a compact, multibranched evergreen shrubs or small tree, commonly 4 to 6 feet in height, but can reach up to 12 feet height. Leaves are glossy, leathery, oblong, about 4 to 6 inches long and are arranged in opposite pairs.
MEDICINAL USES:
A decoction of the root is used after child birth. A decoction is used against bronchial disorders. An infusion of the fresh flowers is said to be a remedy against
incipient tuberculosis and haemorrhage. A decoction is prescribed in the treatment of amenorrhoea and hypertension. An infusion of leaves or flowers is used against headache.
AIM AND OBJECTIVE:
Herbal drugs play a vital role in the management of various liver disorder, most of them speed up the natural healing process of liver. Numerous medicinal plants and their formulations are used in liver disorders in ethno medicinal practices as well as traditional system of medicine in India. According to WHO about 18,000 people die every year due to hepatic disease. Liver diseases remain one of the
serious health problems is the absence of variable liver protective drugs. The common ailments of liver are cirrhosis, cholestasis, hepatitis, portal hypertension,
hepatic encephalopathy, hepatic failure and certain tomours like hepatoma.
The aim of the research is to find out new hepatoprotective drugs from indigenous plants which are potent and nontoxic agents. Present study deals with the hepatoprotective activity leaves of Ixora chenensis.
PLAN OF THE WORK:
1. To investigate the organoleptic and morphological characteristics of Ixora chenensis leaves to establish the pharmacognostical standards of the plants.
2. To carry out preliminary phytochemical analysis of extracts of leaves of Ixora chenensis to establish the different classes of compounds present their leaves.
3. To evaluate the extracts of Ixora chenensis leaves for antioxidant activity by different radical scavenging methods and methods based on reducing ability of extracts.
4. To evaluate the extracts of Ixora chenensis for acute toxicity potential and establish their margin of therapeutic safety.
5. To evaluate the hepatoprotective activity of extracts of Ixora chenensis leaves against carbon tetrachloride induced liver damage in rats.
DISCUSSION:
For screening the hepatoprotective drugs, liver damage is usually induced by CCL4. As a result there is a rise in different liver enzyme levels in serum that is SGOT,
SGPT, TB, AP and also for cholesterol which have been recognized as a sign to the damaged structural integrity of the liver, because they are cytoplasmic in location and
released into circulation after cellular damages.
CONCLUSION:
In conclusion, from the overall result of the biochemical and histopathological examinations, it will be inferred that Ixora chenensis which may be have highest hepatoprotective activity among the four tested plant extracts. This work will be useful for extended for the isolation and structure determination of the hepatoprotective principles
