BACKGROUND:
This prospective study was conducted at Nephrology department in “Meenakshi Mission Hospital and Research Centre” MMHRC) MMHRC: This hospital was located in lake area at Madurai. This is a 750 plus bedded hospital built in late 20th century by Dr. SETHURAMAN (FOUNDER). The hospital was especially built for lower realms of humanity in our country and it provides multispecialty medical and surgical treatment at very high levels. The quality control service for each department has been done and their presentation also has been done in every year. This hospital is a deemed autonomous teaching hospital which have academic programs for paramedical disciplines. This study was conducted between December 2012 – July 2013.
AIM AND OBJECTIVES:
Drug toxicity in hospitalized patients is a frequent adverse event with nephrotoxicity accounting for nearly 20% of all drug toxicity. Hospitalized patients are vulnerable to renal failure from a variety of causes, including diagnostic procedures (1V contrast), sudden decrease in blood pressure (gastrointestinal bleed, sepsis, variceal bleed) and the addition of nephrotoxic medications (aminoglycosides, amphotericin, chemotherapy). Upto 16% of patients with baseline normal renal function who experience renal injury within the hospital setting have medication induced renal failure.
The present study has made an attempt to reveal the following details:
1. To study on various renal diseases reported in the nephrology department of the hospital.
2. Study on patients with drug induced renal diseases.
3. Etiology of drug induced renal diseases.
4. Study on corresponding elevations in laboratory parameters in drug induced renal diseased patients.
5. Clinical management of patients with drug induced renal disease.
PLAN OF THE WORK:
The present dissertation was undertaken to study the incidence of drug induced renal disease and its clinical management.
• Collection of patients admitted with drug induced renal disease in the nephrology unit of the hospital.
• Collection of case history to point out the etiology of drug induced renal disease.
• Corresponding elevations in the clinical parameters are observed.
• Clinical management of drug induced renal disease undertaken is studied.
• Consultation with the Nephrologist.
• Submission of reports obtained.
CONCLUSION:
In this prospective study 538 patients were having various kidney diseases.
Prevalence of kidney disease is very high between age group 51to 60 and 41 to 50 were 160 and 146 respectively, and it is due to metabolic rate, food habits, environment etc.
Sex distribution among the sample population.
It was observed that male (68%) predominance exists in this study compared to females (32%).
Drug induced renal disease:
Drug induced renal disease has occurred in 5.57% of the hospitalized patients coming with various renal diseases during the study period. In this study, 30 patients with drug induced nephrotoxicity have been observed out of this noted 20% female (6) and 80% male (24) patients, it is mainly due to sedentary life style.
Out of these 30 subjcts 22 subjects having intra renal disease,8 subject having pre renal disease due to insufficient in take of water, quality of water, calcium rich diet like cow milk, dry fish, variety of pickles etc.
Population having metabolic disorder like Diabetes mellitus and hypertension were more prone to get drug induced kidney disease because of food habits and life style.
Age distribution In this study, patients with an age group between 10 – 80 were exposed to drug induced renal disease
