The present investigation has been undertaken to study the anticonvulsant activity of chloroform root extract of Aconitum heterophyllum. The plant Aconitum heterophyllum of family Ranunculaceae is an Ayurvedic herb which is known for its significant medical properties. Experiments were conducted following standard procedures. The chloroform extract of Aconitum heterophyllum were evaluated for their invivo antioxidant and anticonvulsant properties and neurotransmitters level. The anticonvulsant activity of CEAH was evaluated using maximal electroshock induced convulsion and pentylenetetrazole induced convulsion models. Diphenylhydantoin was used as standard for MES and Sodium Valproate was used as standard for PTZ. Extracts treated groups showed higher in vivo antioxidant, and anticonvulsant activities. They also showed higher activity in neurotransmitters level. CEAH exhibited similar anticonvulsant activity that of the standard but with lesser magnitude. The result may be attributed to the chemical constituents such as diterpene alkaloids present in it which may be due to their individual or cumulative effect that enhanced anticonvulsant activity and provided scientific evidence to the ethnomedicinal features of Aconitum heterophyllum. These findings could justify the inclusion of this plant in the management of epilepsy
