Study on Lipid Abnormalities in Chronic Renal Failure

Abstract

Dyslipidemia is a fairly common occurrence in CRF patients. Cardiovascular mortality in patients with CRF is related to dyslipidemia. This study was done to identify the lipid abnormalities and its significance in CRF patients by comparing with age, sex and BMI of matched healthy control population. After institutional ethical clearance with an informed consent and with inclusion and exclusion criteria, 56 cases of CRF were taken as study cases and Three fasting lipid profile were estimated. 25 age, sex and BMI matched healthy Population were taken as controls. The data were entered in master sheet and analyzed statistically. Dyslipidemia is seen in CRF patients. The total cholesterol, even though it was high in CRF cases compared with controls, but the change was not significant statistically. Triglycerides showed a statistically significant increase in CRF cases. LDL-C was elevated in CRF cases but the change was not significant statistically. HDL-C on the other hand showed a statistically significant drop compared to controls. These lipid abnormalities may be an important contributing factor to the cardiovascular mortality in patients with CRF

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