This research was to prepare ramipril loaded solid lipid
nanoparticles for controlled release of drug and a trial to improve the bioavailability.
Hot homogenization and ultrasound dispersion were employed to produce SLNs
using biodegradable lipids and non ionic surfactants.
The formulated SLNs were characterized for entrapment efficiency, particle size
and in vitro release studies in phosphate buffer saline PH 7.4.
The nanoparticle colloidal drug delivery system of ramipril prepared type of
lipids and non ionic surfactants obtained better entrapment efficiency.
The better entrapment efficiency of SLNs was obtained with more hydrophilic
surfactants (poloxamer 188) about 85.36% due to the higher HLB value of the
surfactant.
The results revealed that the increase in the surfactant concentration increases
the entrapment efficiency for all formulations and the percentage entrapment efficiency
of various non ionic surfactants was observed in the order of Poloxamer 188 > Tween
80 > Span 20.
The particle size of the formulated ramipril SLNs exhibited nanometer size
range spherical shape particles.
The in vitro release studies revealed that the SLN formulations showed a
prolonged drug release.
SEM analysis of the SLN dispersion showed the spherical shape of the
nanoparticles.
Stability studies indicated that the entrapment efficiency of the SLN was not
affected significantly in the refrigerated storage temperature. However there may be a slight reduction in the entrapment efficiency of the SLN due to the drug expulsion from
the crystal lattice.
The results of the IR studies proved that no interactions between the drug, lipid
and formulations.
It is concluded that the hot homogenization and ultrasound dispersion method, is
a useful method for the successful incorporation of poorly water soluble drug ramipril
with high entrapment efficiency. The prolonged release of the drug from the solid lipid
nanoparticles suggests that the frequency of administration may be reduced. Further it
may be presumed that if the nanometer range particles are obtained, the bioavailability
may be increased. Hence we can conclude that solid lipid nanoparticles provide
controlled release of drug and these systems are used as drug carriers for lipophilic
drugs to enhance the bioavailability of poorly water soluble drugs through nanoparticle
as a drug delivery system
