The present was study to formulate the mouth dissolving
tablets using super disintegrants and evaluating for its characteristics. To enhance the solubility of salbutamal sulphate by using superdisintegrants in the oral cavity.
and to develop mouth dissolving drug delivery system and
enhance the patient compliance.Asthma is defined as chronic inflammatory disorder of the airways in
which many cells a mast cells, esinofils, T-lymphocytes, macrophage,
neutrophils and epithelial cells and other cellular elements play role in
susceptible individual recurrent episodes of wheezing breathless chest fight
and coughing. Anti asthmatics are typically corticosteroids, leuckotriene cormones,
antihistamines, beta two agonist theopylline.
Salbutamol sulphate is B2 adrenergic agonist that stimulator receptors
of smooth muscles in the lungs. Salbutamol is believed to work by
adenylate cyclase, the enzyme responsible for generating cyclic Amp
an intracellular mediator. Increased cylase Amp lead to activating of
intra cellular ionized cyclic Amp prokinase A which inhibits
phosphorylation of myosin and lowers the intracellular ionic calcium
concentration, resulting in relaxation of bronchial and tracheal
smooth muscles, which in turn relieves branchospasm, reducer
airway resistance, facilitates mucous drainage and increases vital
capacity
