This study proves that GFDDS of furosemide can be designed using HPMC K4M as matrix polymer, which provides nearly
zero order release kinetics and thus possienhancement of oral bioavailability of the drug. This study was done as per the method described in section 2.2.2.3. Absorbance
values at max314 nm at different time points were tabulated.
Nizatidine floating tablets were successfully prepared with hydrophilic polymers like HPMC K4M and Poly Ethylene Oxide WSR 1105. All formulations were evaluated for Compressibility Index, Angle of repose and Hausner
ratio. The results indicated that the final blend had good flow and suited for direct compression technique.
From the pre-formulation studies for drug excipient compatibility it was observed that Nizatidine had interaction with citric acid. No physical or chemical incompatibility existed between the drug and other excipients. All formulations were tested for post compression parameters like hardness, thickness,
weight variation, friability and drug content. All estimated parameters were found to be within the limits. This indicated that all the prepared formulations were good.
All formulations were tested for buoyancy properties like floating lag time & total floating time. Almost all the formulations showed satisfactory results. All formulations were tested for in vitro drug release. The optimized formulations among HPMC K4M and Poly Ethylene Oxide WSR 1105 are F2 and F6. These were chosen because of their close similarity with predicted theoretical release profile.
The F6 formulation was chosen as the best formulation among all the other formulations.So stability studies are performed after one month also the formulation is stable
