Ayurvedic is largely practiced using ancient protocols and parameters. Though there is a need of scientific scrutiny of its principles of treatment, very few attempts have been made for its scientific and systemic validation. In the present investigation we tried to assess the toxicity profile of two iron containing bhasmas, swarna makshika and kasis bhasma. No significant Adverse Effect was observed for low dose range of swarna makshika and kasis bhasma tested animal. The higher dose range tested was well above and at an adequate safety distance of the recommended dose in humans. Though the animals treated with high dose of swarna makshika bhasma showed hepatotoxicity and for kasis bhasma high dose treated groups shows neurotoxicity or CNS depressant action. This study indicates that there are chances of hepatotoxicity and neurotoxicity along with the clinical administration of higher doses of swarna makshika and kasis bhasma respectively .while low doses of both bhasmas was found to be safe. So both bhasmas are considered to be safe at clinically administered doses (9mg/kg for S.M.B and 4.5mg/kg for K.B). However, further detailed studies are required to know the long term chronic toxicity of swarna makshika and kasis bhasma
