Comparative Evaluation of Inclusion Complex of Aceclofenac Prepared by different Techniques.

Abstract

Cyclodextrins Are Cyclic Oligosaccharides Containing At Least Six D-(+)- Glucopyranose Units Attached By Α (1Æ4) Glucoside Bonds. The Three Natural Cyclodextrins, Α, Β, And Γ Differ In Their Ring Size And Solubility. They Contain 6, 7 Or 8 Glucose Units, Respectively An Inclusion Complex Of Aceclofenac With Β- Cyclodextrin Could Be Prepared Successfully By Kneading In A Molar Ratio Of 1:2 And This Was Confirmed By Phase Solubility Studies, UV Spectrophotometry, Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, X-Ray Diffraction, Drug Content Estimation, In Vitro Dissolution Study And Stability Studies

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