The objective of any drug delivery system is to provide therapeutic amount of drug to targeted site in body to achieve the desired therapeutic effect. In recent years, attention has been focused on the development of new drug delivery system rather than invention of new molecules. Because the development cost for new drug molecule is very high and possibility of repenting successful drugs by applying concepts and techniques of controlled release drug delivery systems. The preformulation parameters like organoleptic properties, angle of epose, bulk density, tapped density, Hausner’s ratio, carr’s index and compressibility index of pure drug was evaluated and complied with the pharmacopoeia specifications. FTIR studies showed that there was no interaction between drug and polymer. Controlled release matrix tablets of perindopril erbumine was formulated by using polymer like HPMC K100 M and Xanthan gum. The formulated batches were evaluated for physicochemical parameters and dissolution profiles. The physical properties like hardness, weight variation and friability of majority of the batches complied with the pharmacopoeial specifications. The drug content of all tablets was in the range of 93 – 100%. •In vitro dissolution study of all the formulations was done in acid buffer pH 1.2 and phosphate buffer pH 6.8. The release rate was faster with Xanthan gum compared to HPMC.It has been observed that using of combination of polymers (F9) retarded the drug release up to 24 hrs satisfactorily. The cumulative % drug release was observed for F9 formulation 99.74. Hence F9 was taken for kinetic studies. The kinetic study was carried out for F9 which showed that the drug release follows zero order ( regression coefficient 0.993) was adequately controlled the drug and anomalous non –fickian (N >5) transport of diffusion from the release from the formulation with complete release in 24hrs mad eit to select as an optimized formulation compared with other formulations
