The best new therapeutic entity in the world is of little value without an appropriate delivery system. Tablet delivery systems can range from simple immediate release formulations to complex extended or modified release dosage forms. The most important role of drug delivery system is to get the drug delivered to the site of action in sufficient amount and at the appropriate rate; however it must also meet a number of other essential criteria. These include physical and chemical stability, ability to be economically mass produced in a manner that assures the proper amount of drug in each and every dosage form and in each batch produced and as far as possible patient acceptability the drug and the delivery systems cannot be separated.
The main objective of the experimental work undertaken was to develop and evaluate the formulation of Loxoprofen sodium Tablets. The results of the study done are summarized as the tablets manufactured also possessed acceptable parameters almost resembling the market sample and the coating process of the tablets was optimized with a good release of drug from the coated tablets. From the results it can be concluded that Loxoprofen sodium Tablet was formulated and evaluated . Several trials have been taken to optimize and develop a robust formulation. Various processing problems were encountered during the formulation development and these were overcome with proper optimization of composition of formulation ingredients and processing conditions. The coated tablets were evaluated for the physical as well as chemical attributes and were found to be satisfactory in comparison to the market sample. Two reproducibility batches (T11 and T12) were taken for the finalized batch ie.T10 and were charged for stability studies at accelerated condition. The stability study for 3 months shows that the formulation is stable enough at 400C/75%RH
