Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived after assisted reproductive technologies (ART ). This retrospective study included singleton and twin pregnancies conceived after ART in the period from January 1, 2007 until December 31, 2008. The study variables were maternal age (years), parity, body mass index (BMI; kg/m2), week (≤366/7 and ≥37) and mode of delivery (vaginal and cesarean section), birth weight (grams) and APGAR score (≤7; 8-10). During the study period, there were 195 pregnancies after ART that fulfilled inclusion criteria. We found no between-group difference in parity (χ2=0.0133; P=0.9081), but such difference was found in mean age (t=2.0486; p=0.0419) and BMI (χ2=31.038; P=0.001). A statistically significant difference was recorded in preterm delivery rate (χ2=25.539; P=0.001), average duration of pregnancy (t=12.8591; p=0.001), average birth weight (t=10.5446; P=0.001) and mode of delivery (χ2=13,691; P=0.001). A statistically significant difference was found in low birth weight babies (χ2=102.02; P=0.001) and APGAR score (χ2=19.96; P=0.001), but there was no difference in the prevalence of small for gestational age babies (χ2=0.90629; P=0.635). In conclusion, this study indicated the perinatal outcome after ART to be considerably poorer in twins than in singletons.Cilj ove studije bio je istražiti razliku u perinatalnom ishodu jednoplodnih i blizanačkih trudnoća nakon medicinski potpomognute oplodnje (MPO). Ispitana je medicinska dokumentacija jednoplodnih i blizanačkih trudnoća u žena koje su rodile živorođenu djecu nakon MPO u dvogodišnjem razdoblju u Klinici za ženske bolesti i porode, KBC Split, od 1. siječnja 2007. do 31. prosinca 2008. godine. Istraživane varijable bile su dob, paritet, indeks tjelesne mase (kg/m2), navršeni tjedan poroda (prijevremeni ≤366/7 i terminski ≥37), način dovršetka porođaja (vaginalno i carski rez), porođajna masa djeteta (grami), trofičnost djeteta (hipertrofično, eutrofično i hipotrofično) i APGAR zbroj novorođenčeta (≤7, 8-10). U promatranom razdoblju 195 trudnica je rodilo nakon neke od metoda MPO. Između rodilja s jednoplodnom i blizanačkom trudnoćom koje su zanijele nekom metodom MPO nije bilo razlike u paritetu (χ2=0,0133; P=0,9081), dok su razlike pronađene u prosječnoj dobi (t=2,0486; p=0,0419) i indeksu tjelesne mase (χ2=31,038; p=0,001). Statistički značajna razlika nađena je u učestalosti prijevremenog poroda (χ2=25,539; P=0,001), prosječnom trajanju trudnoće (t=12,8591; p=0,001) i prosječnoj porodnoj masi djece (t=10,5446; P=0,001). Blizanačke trudnoće u usporedbi s jednoplodnim trudnoćama nakon MPO češće se dovršavaju carskim rezom (χ2=13,691; P=0,001). Pronađena je statistički značajna razlika između istraživanih skupina u rađanju djece niske porodne mase (<2500 g) (χ2=102,02; P=0,001) i APGAR zbroju novorođenčadi (χ2=19,96; P=0,001). Nije bilo statistički značajne razlike u učestalosti rađanja hipotrofične djece između istraživanih skupina (χ2=0,90629; P=0,635). U zaključku, perinatalni ishod nakon MPO je lošiji u blizanačkih nego u jednoplodnih trudnoća
