SocietĂ Chimica Italiana, Divisione di chimica dell'ambiente e dei beni culturali
Abstract
The carcinogenicity of nickel compounds has been confirmed and corroborated by numerous epidemiological studies in humans and carcinogenesis bioassays in animals. We also found that an excellent tumour marker recently discovered and specifically induced by nickel, Cap43 protein,
has a new mono-histidinic motif consisting of ten amino acids TRSRSHTSEG repeated three times in the C-terminus
which is able to bind several metal ions in a cooperative way
