The novel highly potent biologically stable metabotropic glutamate receptor 5 (mGlu5) selective positron emission tomography (PET) probes, [11C]-3-fluoro-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]FPTB) and [11C]-3-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]PTB), have been developed using Pd-mediated [11C]cyanation of 2-(2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl)pyridine (Br-FPTB) or 2-(2-(3-bromophenyl)-2H-tetrazol-5-yl)pyridine (Br-PTB). The elaboration of the reaction conditions and evaluation of these 11C-labeled probes (([11C]FPTB) and ([11C]PTB)) will be discussed.WMIC2018(World Molecular Imaging Congress)でのポスター発
