The development of novel antioxidants showing a stronger radical-scavenging activity than natural antioxidants has attracted considerable interest to remove reactive oxygen species, which are known to induce oxidative stress and associated diseases. We herein report the synthesis, radical-scavenging activity, and redox behavior of planar catechin derivatives, in which catechol and chroman moieties in natural (+)-catechin are constrained to be planar. The spectroscopic and kinetic studies have demonstrated that the rate of the scavenging reaction of galvinoxyl radical by the planar catechin is about 5-fold faster than that by (+)-catechin in deaerated acetonitrile.International Society for Free Radical Research 13th Biennial Congres
