A Bystander effect observed in boron neutron capture therapy: A study of the induction of mutations in the HPRT locus

Abstract

To investigate bystander mutagenic effects indued by alpha-particles during boron neutron cupture therapy, we mixed cells that were electroporated with boroncaptate sodium (BSH), which led to the accumulation of B-10 inside the cells, and cells that did not contain the boron compound. The BSH containing cells were irradiated with alpha particles produced by B(j,a)Li reaction, where as cells without boron were affected only by the 1H(n,r)2H and 14N(n,p)14C reactions

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