'Publishing House for Science and Technology, Vietnam Academy of Science and Technology'
Abstract
Viburnum sambucinum is a small woody tree belongs to the genus Viburnum (Caprifoliaceae), mainly distributed in Vietnam, Lao and Cambodia. Extensive studies of the genus Viburnum have led to the identification of many compounds, such as diterpenes, triterpenes, iridoids, monoterpenes, sesquiterpenes, flavonoids, lignans, etc. In previous study, we reported 6 terpenoids isolated from the leaves of Viburnum sambucinum. In this study, we describe the isolation and structural characterizations of four compounds hupehenol D (1), hupehenol A (2), 12β-hydoxy-3,15-dioxo- 20,21,22-23,24,25,26,27-octanordammanran (3), luteolin (4) and in vitro cytotoxic activities of ten compounds (1-10) from the leaves of Viburnum sambucinum. Compound 1 and 3 exhibited significant cytotoxic activity against 4 cancer cell lines with IC50 value 4.71±0.03-5.35±0.04 μM. The compounds 2, 4, 6, 7 and 9 displayed week cytotoxicity with IC50 values ranging from 9.31± 0.12 to 82.06±0.94 mM
