We construct a Lagrangian formulation of \Nf supersymmetric mechanics with
hyper-K\"{a}hler sigma models in a bosonic sector in the non-Abelian background
gauge field. The resulting action includes a wide class of \Nf supersymmetric
mechanics describing the motion of an isospin-carrying particle over spaces
with non-trivial geometry. In two examples we discuss in details, the
background fields are identified with the field of BPST instantons in the flat
and Taub-NUT spaces.Comment: 11 pages, LaTeX, no figures, PACS: 12.60.Jv, 03.65.-w, 11.30.Pb,
14.80.Hv; Talk, it will be published in the proceedings of the XIX
International Colloquium "Integrable Systems and Quantum Symmetries", Prague,
17-19 June 2010; reference added, minor correction