Human element is very significant work component in a work system. Human condition said unsafely if the worker’s healthy nd safety become annoyed. Bad work postures can be risk factor (physical risk factor) for appearing the indication of work related musculoskeletal disorders (WRMSD’S). The research is experiment in laboratory; it’s purposed to find the wo y influence and the rise weight to musculoskeletal disorders. The research object is manual material handling static work, namely; to lift, to bring down and to move rice sack with 15 kg, 10 kg and 15 kg weight. Musculoskeletal fatigue is indirectly measured by measuring heart beating. In the experiment found the result of work activity in woman and man subject that give enough significant to musculoskeletal disord rs, the rise weight doesn’t give influence to musculoskeletal disorders and the interac ion between of the two do not give any significant influence
