Objective: The objective is to compare the radiological outcome of closed interlock intramedullary nailing versus dynamic compression plating in closed tibial fracture. Methodology: The study took place in Department of orthopedics Nishtar Hospital Multan from 9th July 2016 to March 2017. Study design is randomized controlled trials. There were 302 patients divided in two equal groups of 151. Permission was taken from the ethical committee of Nishtar Hospital. The 302 patients in age group 20-50 years of both genders meeting the inclusion and exclusion criteria attending the outpatient clinic or admitted to the orthopedics department through emergency were included in the study. All the data entered and analyzed using computer software SPSS version 10. For quantitative variables like age and duration of fracture mean and standard deviation was calculated. For categorical variables like gender, malunion and infection frequency and percentage were calculated. Chi-square test was applied to compare the malunion and infection in both groups. A p value 0.05 was considered statistically significant. Results: The 100% (n=302) patients were divided into 2 groups equally, 151 in each, i.e. intramedullary nail (group 1) and dynamic compression plating (group 2). The main outcome variables of this study were the malunion and infection. It was observed that malunion presented as 57% (n=86) and 70.9% (n=107) in group 1 and group 2 respectively. It was also observed that infection presented as 23.2% (n=35) and 37.1% (n=56) in group 1 and group 2 respectively. After applying chi-square test, it was noted that malunion associated with groups having p-value 0.012. But it was not associated with gender, stratified age and duration of fracture having p-values 0.497, 0.800 and 0.218 respectively. Similarly, after applying chi-square test, it was noted that infection associated with gender and groups having p-values 0.007 and 0.008 respectively. But it was not associated with stratified age and duration of fracture having p-values 0.565 and 0.344 respectively. Conclusion: Closed interlock intramedullary nailing has malunion and infection rates less than dynamic compression plating. So closed interlock intramedullary nailing is preferred method of closed tibia diaphyseal fracture treatment. Keywords: Intramedullary nailing, closed tibia diaphyseal fracture, dynamic compression plating
