The aim of the present study was to assess the sulphate (SO2−4 ) and iron (Fe) contamination and seasonal variations in the water resources (groundwater, surface water, and mine water) of the West Bokaro coalfield region, India. One hundred and twenty-four water resources samples were collected from the coalfield during the post- and pre-monsoon seasons. The concentrations of SO2−4 were determined using ion chromatography and Fe concentrations were analyzed using inductively coupled plasma mass spectrometry. A statistical analysis was used to easily understand the seasonal variations of the elements in the water resources of the area. The concentrations of SO2−4 and Fe in the water resources were higher in the pre-monsoon season than in the post-monsoon season, irrespective of location. The water resources of the coalfield were contaminated with high concentrations of SO2−4 and Fe, and would require suitable treatment before drinking, domestic and industrial uses