A safety relief valve is a simple hydro-mechanic device, needed to avoid overpressure transients inside hydraulic circuits. Such valves are a critical part of the hydraulic system of aircraft; hence their performances must be adapted to a specific nominal pressure level and design requirements. In the following paragraphs the authors will address the issue of designing and validating a safety valve through a hybrid CFD/MATLAB-Simulink® approach. The main constraints are the geometrical dimensions and the need to limit the weight of the device. A significant part of the work consists of gathering all the possible information available in the literature, dealing with the best design practices to achieve the performance objective. Thanks to a robust computational procedure, it should be possible to reduce the amount of “physical” prototypes required to validate the functionality of a safety relief valve. The process presented uses a numerical computational fluid dynamic (CFD) approach, to define the pressure field inside the valve and the forces acting on it; identifying the force distribution inside the valve is paramount to address the performance evaluation of the valve itself. The first step deals with the definition of a computer aided design (CAD) model of the valve. Then the CFD software uses the above-mentioned CAD model to define the domain of the problem. Once obtained the pressure field, it is possible to integrate it through the surface of the valve, thus obtaining the forces acting on the moving part (poppet). After the numerical scheme has been calibrated, some investigations are done to reduce the computational cost: the main aim is to run a complete simulation (meshing and solving) on a standard computer. Some of the positions (i.e. strokes) of the valve have been simulated as static, hence a steady-state calculation has been applied to solve the motion field. Another important result consists of creating a MATLAB-Simulink® model, capable to reach results comparable to the CFD simulation, but in shorter times. While the CFD model can provide high quality results, the MATLAB-Simulink® calculation should be used to create a “first guess” instrument, useful to address the very first valve geometry. The implementation of the Look-Up Tables (LUTs) links the MATLAB-Simulink® model to the CFD simulation, but increases the time required to obtain a solution: on the other hand, this reduces the amount of equation-modeled quantities, delivering a greater precision to the calculations