This work concerns the study of some important physical and mechanical properties of a wool fabric treated with a roll-to-roll atmospheric plasma jet equipment. The plasma pilot unit, based on a postdischarge technology, was equipped with an innovative plasma-to-fabric contactor, which promotes a relevant penetration of plasma through the fabric structure and geometrically defines the atmosphere. Wool fabrics were processed at three different velocities (1, 3 and 6 m/min); the other process variables were kept constant. Tensile strength, elongation at break, surface thickness, wettability and air permeability increased after the plasma treatment, while several low-stress mechanical properties, strictly related to the handle, were not modified. SEM analysis was also carried out to better interpret the above macroscopic results