Supply Chain Management (SCM) is management of material, money, men, and information within and across the supply chain to maximize customer satisfaction and to enhance competitive advantage. However, the characterization of the current business practices by variation in demands and differences in customer requirements has motivated many firms to be responsive. In the light of this, the paper examines how these firms respond to these changes so as sustain and further create competitive advantages. One hundred and fifteen (115) manufacturing companies, basically medium/large companies formed the sample of the study and data was analyzed using multiple regression analysis. The result revealed positive association between Supply Chain Responsiveness (SCR), SCM practices and Competitive Advantage. Finally, the study provides suitable recommendation on the scope for improvement based on current levels of various predominant SCM practices and SCR criteria that directly impact competitive advantage of a firm, so as to make the organizations more competitive. Key words: Supply Chain Practices, Responsiveness, Competitive Advantage, Information Sharing.