Perhaps the two most often studied and empirically supported organizational factors that can promote the acceptance of technology by the end users are training and participation. The science of training is well established. Not surprisingly, well designed training programs have been shown to promote end user acceptance of technology. The key is to design the training program according to the scientific evidence. Well designed training not only transfers knowledge and skills about the technology, but it can also bring understanding of the technology through education and can create feelings of involvement in decisions. In addition, training can lead to several other important variables for the acceptance of technology including self-efficacy and intrinsic motivation. This paper reviews the theoretical knowledge on what leads to successful technology implementation and how this can be translated into specifically designed processes for successful technology change in Nigerian health-care organizations. Keywords: Safety, information technology, patients, and health-care