A project of the influence of Christos Drossinakis on model biophysical, biochemical and biological systems has been conducted. His influence is with infrared thermal field and electromagnetic fields (e.m. fields). In this study an experiment on hamsters with malignant tumors was performed. The hamsters are prepared by Reneta Toshkova. Spectral analysis methods are Non-equilibrium spectrum (NES) and Differential non-equilibrium spectrum (DNES) for 1% solutions of blood serum from hamsters with cancer and healthy hamsters were investigated. Drossinakis had an effect on hamsters with cancer. Results are obtained with the DNES method according control serum samples of hamsters with cancer and healthy hamsters. The spectrum was obtained in the range (-0.0937 eV; 13.23 μm; 755 cm-1) - (-0.1387 eV; 8.95; μm; 1117 cm-1). The average energy (∆EH...O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of Drossinakis measured by NES- and DNES-methods. The result ∆E=-0.0071±0.0011 eV is according control serum samples of hamsters with cancer and is ∆E=-0.0035±0.0011 eV for healthy hamsters. These results suggest the restructuring of ∆EH...O values among H2O molecules with a statistically reliable increase of local extremums in DNES-spectra. Local extremum was obtained at (-0.1212) eV, which is an indicator of anti-inflammatory effect. Also, a local extremum was obtained at (-0.1387) eV, which is an indicator of inhibition of development of tumor cells at the molecular level. The effects of Drossinakis influence– anti-inflammatory, antioxidant, development inhibition of cancer cells are shown. This article deals with the review of the basic biophysical-biochemical and biological processes underlying the influence of Drossinakis. The authors are studying their physical-chemical properties and biophysical and biological effects on the organism of hamsters. Another research by Toshkova have shown that the cancer hamsters influenced by Drossinakis have increased their life span. Keywords: effect of Drossinakis, serum of hamsters, anti-inflammatory, antioxidant, NES, DNES. DOI: 10.7176/JHMN/58-1