In this paper, a mathematical model consisting of a prey-predator involving a prey refuge and infectious disease in the predator has been proposed and analyzed. Two types of functional responses are used to describe the feeding of the predator on the available prey. The existence, uniqueness and boundedness of the solution of the system are discussed. The dynamical behavior of the system has been investigated locally as well as globally using suitable Lyapunov function. The persistence conditions of the system are established. Local bifurcation near the equilibrium points has been investigated. The Hopf bifurcation conditions around the positive equilibrium point are derived. Finally, numerical simulations are carried out to specify the control parameters and confirm the obtained results Keywords: Prey-Predator, Disease, Refuge, Stability, Bifurcation
