In this paper, bioeconomic model for Tilapia (Oreochromis niloticus) – Nile perch (Lates niloticus) fishery in polluted environment with the constant harvesting efforts is developed. The model analysed to get maximum sustainable yield (MSY) points and the corresponding conditions for existence established. The equilibrium points of the model found and the conditions for their existence established. The stability analysis of the interior equilibrium point is investigated by using Jacobian matrix method. Later, numerical simulations and their corresponding graphs revealed that water pollution has significant effects on the maximum sustainable yields of both Tilapia and Nile perch produces. These effects also manifests the rapid changes of species population at the interior equilibrium point. Keywords: bioeconomic model, fishery, Tilapia, Nile perch, harvesting and water pollution