The study investigated the effect of demographic factors on attitude towards disable employees in public and private sector organizations in Ghana. Using cross-sectional survey design, data were collected from 188 participants within the Greater Accra Metropolis with reliable questionnaire. Independent t-test was used to test each of the hypotheses in the study. It was observed that, older employees demonstrated significantly more positive attitude towards disable employees than younger employees. Similarly, employees with higher level of education showed significantly more positive attitude towards disable employees than their counterparts with lower level of education. However, irrespective of sector of employment of the employee, attitude towards disable employees was not significantly different. The implications of the findings and limitations are discussed. Keywords: Attitude, disable employees, demographic factors, public sector, private sector, Ghan