This study was carried out to assess the effect of ethanolic leaf extract of Sida acuta on the kidney electrolytes of adult Wistar rats. Forty five rats weighing between 140-180g were assigned to three groups (A, B and C) with fifteen animals each. Group A served as the control while groups B and C served as the experimental groups and received 100mg/kgbw and 200mg/kgbw of the extract respectively for fourteen days. All the animals were sacrificed after fourteen days. Blood was collected by cardiac puncture for biochemical analysis of serum electrolytes. Serum chemistry revealed significantly raised sodium and decreased potassium levels in animals treated with 100mg/kgbw, but chloride, creatinine and potassium not significantly affected (P>0.05). Animals treated with 200mg/kgbw of the extract had significantly raised sodium levels, but reduced potassium, chloride and creatinine relative to control (P<0.05). From the result of this experiment, it is concluded that the administration of ethanolic extract of Sida acuta leaves could have adverse effects on the kidney electrolytes of Adult Wistar rats at the doses and duration used in the course of this experimentation Keywords – Biochemical, Electrolyte, Kidney, Serum, Sida acut
