This study assessed the effect of ethanolic extract of Sida acuta leaf on the micro-anatomy of the kidney of Wistar rats. Thirty adult Wistar rats were separated into 3 groups A, B and C (n=10 per group). The Wistar rats were subjected to different doses of ethanolic extract of Sida acuta in order to evaluate the possible micro-anatomy/morphological changes in the kidney following the administration of the extract. The rats in group A were regarded as control and they received only distilled water throughout the period. The rats in group B and C were the treated groups and received ethanolic extract of Sida acuta leaves daily at doses 100 and 200mg/kgbw orally for 14 days respectively. The animals were sacrificed on the 15th day by cervical dislocation and the kidney excised. Fixed in 10% formal saline and processed for light microscopy using H&E staining methods. Finding from rats’ weight that there was a significant (P<0.05) decrease in body weight of the treated rats compared with the control group. The histological study revealed compressed renal corpuscle, increased bowman’s space and constricted collecting tubule which may adversely affect renal functions. Key words: Sida acuta, Kidney, histomorphology, biochemica
