Background: Hepatitis B virus is one of the major etiological agents for parenterally acquired hepatitis. Viral hepatitis during pregnancy is associated with high risk of maternal complications. This study was conducted to determine the prevalence of HBV infection in pregnant women, and to find out its associated risk factors in Jazan region south KSA. Patients & Methods: A random sample of 537 pregnant females who attended Jazan general hospital and randomly selected primary health care centers in Jazan region - before 38 weeks of gestation - constituted the target population of the present study. All women were screened for HBsAgd by using HBsAg Rapid Test Device (ACON). Results: The overall prevalence of HBV virus among the women was found to be 4.1% (95% CI: 2.7 - 6.1). The prevalence of HBV according to age showed that women less than 20 years are free of HBV, whereas for other age groups HBV prevalence is found to increase with increase in age. Regarding the associated risk factors, women with history of hospitalization, and jaundices showed a significant association with anti- HBV seropositive. Dental histories, blood transfusion and history of surgery did not prove significant association with HBV. Conclusion: Prevalence of Hepatitis B virus infection in pregnant ladies was 4.1%. Past history of hospitalization and jaundices are important risk factors for transmission of infection. The study suggests expansion of the Hepatitis B vaccination program to reduce the risk of HBV among pregnant women. Key words: Hepatitis B virus, Pregnancy, Prevalence, Risk factors
