Background: Myocardial infarction is a life threatening disease that influences the physical, psychological and social dimensions of the individual. Improper lifestyle is one of the causes of this disease. The designing and implementing of nursing intervention protocol for MI patients could be one of the important and fundamental steps in improving MI patients outcomes. Aim: The aim of this study was to examine the impact of a designed nursing intervention protocol on myocardial infarction patient’s outcomes as indicated by higher post total mean knowledge scores, higher post total mean practices scores and high level of compliance to lifelong instruction. Research hypotheses: H1. Patients who will be exposed to a designed nursing intervention protocol will have a higher post total mean knowledge scores; H2. Patients who will be exposed to a designed nursing intervention protocol will have a higher post total mean practices scores; H3. Patients who will be exposed to a designed nursing intervention protocol will have a high level of compliance to lifelong instruction. Design: A quasi-experimental research design was utilized in this study Sample: A convenience sample of 40 adult male and female MI patients. Setting: The cardiac care units at a selected Cairo University Hospital were recruited to fulfill the aim of this study. Tools: Four tools were formulated& tested to collect data pertinent to the study; Socio-demographic and medical data sheet, Pre/Post knowledge questionnaire sheet, an Observational checklist and Compliance assessment sheet. Structured interview, reviewing medical records and direct observation were utilized for data collection. Results: The study results revealed that the post total mean knowledge scores of the studied subjects is increased significantly with value of t= 20.6 at p=0.000, higher post total practice scores among the studied subjects with t& p values (t=5.6 at p= 0.000 ) also, studied subjects had mild to high compliance level regarding the lifelong instructions. Conclusion: It can be concluded that, enrichment of patients' knowledge and practices in relation to their condition and utilization of the effective nursing intervention protocol as an approach of care could have a positive impact upon improvement of patients' outcome. Recommendations: The study recommended Conduction of further studies in order to assess the effectiveness of the designed protocol on patients' outcome regarding different cardiac disorders with replication of this study on a larger probability sample from different geographical locations at the Arab Republic of Egypt, in addition to establishment of cardiac rehabilitation center in the different heath care organizations. Keywards: Nursing intervention protocol, Myocardial Infarction, Outcomes, Cardiac care units
