IGFBP-4 regulates adult skeletal growth in a sex-specific manner.

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Publication date
1 April 2017
Publisher
MaineHealth Knowledge Connection

Abstract

Insulin-like growth factor-1 (IGF-1) and its binding proteins are critical mediators of skeletal growth. Insulin-like growth factor-binding protein 4 (IGFBP-4) is highly expressed in osteoblasts and inhibits IGF-1 action

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