Previous research on pharmacy faculty quality of work life lacks a thorough, well-conceived theoretical foundation, especially in critical areas such as work satisfaction and turnover intentions. The objectives of this study are to develop a comprehensive measure of pharmacy academician work satisfaction and determine the contribution of work life variables toward pharmacy academician work satisfaction, job turnover intentions, and self-efficacies. An e-mail survey sent to pharmacy faculty elicited responses on various single and multi-item measures of quality of work life variables. Factor analytic procedures were used to evaluate the validity and reliability of the work satisfaction scale. Multiple regression procedures were used to identify predictors of the satisfaction, turnover, and self-efficacy constructs. The satisfaction measure demonstrated construct validity, while each of the six domain subscales exhibited internal consistency reliability. Institutional support and intradisciplinary consensus variables were commonly identified as predictors of satisfaction, stress, and self-efficacies for pharmacy faculty. Administrators might consider these results when implementing policies that may impact organizational climate and faculty morale. There is still an opportunity to further examine quality of work life among pharmacy faculty